Please note that all times mentioned are CET (Central European Time)
Submitted program are always an exciting part of the Congress. The most notable and exciting work from all abstracts submitted to the congress will be honored with an oral presentation in workshops. Workshop sessions will include pre-recorded presentations with a live connection for discussion. Oral presenters will send in pre-recorded video presentations of their work and will be asked to participate in a question and answer session in real time where presenters are expected to answer questions from the audience about their work.
Cellular Immunology Workshops
| Workshop – WS.T1.01 |
| B Lymhocyte Regulation & Function |
| Date & Time: September 2, 2021 / 11:30 – 12:45 |
| Chairs: TBA |
| Ondrej Suchanek, United Kingdom – Tissue-resident B cells orchestrate macrophage phenotype and function in non-lymphoid organs |
| Dessi Malinova, United Kingdom – Novel players in B cell antigen uptake and trafficking |
| Marta Ferreira Gomes, Germany – Most isotype-switched memory B cells reside in bone marrow or spleen |
| Nieke van der Bolt, Netherlands – Evolution of the SARS-CoV-2 specific B cell and antibody repertoires over time |
| Lina Petersone, United Kingdom – IL-21 is a key regulator of chronic germinal centre responses in CTLA-4-deficient mice |
| Casper Marsman, Netherlands – Termination of CD40L signaling drives human naïve B cell differentiation into antibody-secreting cell formation |
| Manuel D. Diaz Muñoz, France – The RNA-binding protein HuR is essential for maintenance of the germinal centre response |
| Workshop – WS.T1.02 |
| T Cell Development |
| Date & Time: September 3, 2021 / 09:30 – 10:45 |
| Chairs: TBA |
| Juliette Roels, Belgium – An integrated multi-omics view on human T cell development |
| Florencia Morganac, Netherlands – Single-cell transcriptomics reveals discrete steps in regulatory T cell development in the human thymus |
| Jiří Březina, Czech Republic – The rules of engagement of dendritic cells in thymic cooperative antigen transfer |
| Yanran Zhao, Australia – Functional characterisation and transcriptomic analysis of antigen-specific CD8 T memory stem cells (TSCM) generated from clonally expanded single TSCM cells {in vitro} |
| Fanny Lafouresse, France – Unique cellular sources of CXCR3 ligands direct intranodal T cell positioning and effector/stem-like memory fates following viral infection |
| Nesrine Marzougui Ep Essalah, Germany – Relevance of Th17-specific epigenetic signature genes for Th17 differentiation and function |
| Saumya Kumar, Portugal – Developmental bifurcation of human T follicular regulatory cells |
| Workshop – WS.T1.03 |
| Innate Immunity |
| Date & Time: September 1, 2021 / 11:15 – 12:30 |
| Chairs: TBA |
| Ana Lopes, Netherlands – Deciphering the role of cDC2 in Sjögren’s Syndrome: transcriptomic profile reveals an enhanced antigen uptake and altered antigen processing associated with IFN-signature |
| Anne Dudeck, Germany – Directional mast cell degranulation of tumor necrosis factor into blood vessels primes neutrophil extravasation |
| Manuel Stecher, Germany – Mitochondrial Fusion is Critical for Mast Cell Development |
| Mihai Valache, Italy – Inositol 1,4,5-trisphosphate 3-kinase B promotes Ca2+ mobilization and the inflammatory activity of dendritic cells |
| Arzuhan Koç, Turkey – Investigating the Molecular and Functional Interaction between Human Macrophages and HiPSC-derived Cardiomyocytes by an {in vitro} Arrhythmia Model |
| Giacomo Sidoti Migliore, Italy – Bacterial lysate enhances protective mucosal immunity via increased expression of antimicrobial peptides |
| Guido Wabnitz, Germany – Inflammation induces CCR5-positive pro-NETotic neutrophils via TNFR2 signaling |
| Workshop – WS.T1.04 |
| Innate Lymphoid Cell |
| Date & Time: September 3, 2021 / 14:30 – 15:45 |
| Chairs: TBA |
| Karlo Mladenić, Croatia – NKG2D ligand recognition by γδ T cells drives steatohepatitis and fibrosis in MAFLD |
| Luke B Roberts, United Kingdom – MicroRNA-142 is a critical regulator of group 2 innate lymphoid cell homeostasis and function |
| Jeremy Goc, United States – Dysregulation of ILC3s unleashes progression and immunotherapy resistance in colon cancer |
| Noe Rodriguez Rodriguez, United Kingdom – Identification and characterisation of novel NK cell-restricted aceNK progenitors |
| Maxime Boy, France – {TET2/IDH} mutations in Myelodysplastic Syndrome patients disrupts Natural Killer cell’s biology |
| Louise Rethacker, France – Characterization of Human Innate Lymphoid Cell Subsets in Healthy Lymph Nodes |
| Sophie Flommersfeld, Germany – Adaptive-like NK cell responses are composed of circulating and resident lineages |
| Workshop – WS.T1.05 |
| Lymphocyte Differentiation |
| Date & Time: September 4, 2021 / 10:30 – 11:45 |
| Chairs: TBA |
| Dirk Baumjohann, Germany – Temporal dissection of the T cell-intrinsic factors that maintain T follicular helper cell identity and germinal centers |
| Dakota Rogers, Canada – Pre-existing chromatin accessibility and gene expression differences among naïve CD4+ T cells influence effector potential |
| Jun Dong, Germany – Mobilization of tissue-resident memory CD4+ T lymphocytes and their contribution to a systemic secondary immune reaction |
| Mark Mensink, Netherlands – Proteomic features reflecting unique properties of human thymus-derived and ex vivo regulatory T cells are not present in TGF-beta-induced regulatory T cells |
| Gabriela Virdzekova, United Kingdom – Akt modulates differentiation of CD8+ memory T cell precursor populations but is dispensable for translational regulation |
| Gloria Tucci, Italy – T regulatory cells oscillate between a TNF-producing and a TNFR2-expressing status |
| Yin Xiao, Germany – Lack of NFATc1 SUMOylation prevents autoimmunity and alloreactivity |
| Workshop – WS.T1.06 |
| Immune Response Regulation: Cellular Mechanism |
| Date & Time: September 1, 2021 / 16:00 – 17:15 |
| Chairs: TBA |
| Maryam Amini, Germany – Role of purinergic signaling in regulating IL-1alpha mediated inflammation in chronic kidney disease |
| Marca Wauben, Netherlands – Cell-derived vesicles present in human milk dampen innate and adaptive immune responses and enhance epithelial barrier function |
| Johanna Kotrba, Germany – Mast cell secretory granules are endogenous c-type lectin receptor ligands skewing dendritic cell function towards Th2/Th17 response |
| Alaz Özcan, Switzerland – CCR7-guided neutrophil redirection to skin-draining lymph nodes regulates cutaneous inflammation and infection |
| Konstantinos Katsoulis Dimitriou, Germany – Peripheral mast cell-derived RANKL is a prerequisite for lymphocyte egress from distant lymph nodes |
| Tyrza Van Leeuwen, Netherlands – Enrichment of bioorthogonal antigens from dendritic cells to study antigen processing on peptide level |
| Cynthia M. Fehres, Netherlands – Autoantibodies isolated from Systemic Sclerosis patients targeting the angiotensin II type 1 and endothelin-1 type A receptor induce endothelial cell activation and pro-fibrotic cellular responses |
| Workshop – WS.T1.07 |
| T Lymphocyte Function |
| Date & Time: September 2, 2021 / 17:15 – 18:30 |
| Chairs: TBA |
| Jun Abe, Switzerland – CD8+ T cells require signal 3 from non-antigen-presenting cells for optimal clonal expansion |
| Marta Fortunatoi, Italy – IL-10 engineered Dendritic Cells modulate allogeneic cytotoxic CD8+ T cells response {in vitro} |
| Bin Qu, Germany – Targeting the microtubule-network to improve CTL killing capacity in dense 3D matrices |
| Michael Berger, Israel – Systemic hypoxia inhibits T cell response by limiting mitobiogenesis via matrix substrate-level phosphorylation arrest |
| Alexandra H Mandarano, United States – Copper homeostasis is required for T cell activation |
| Lucy C. Garner, United Kingdom – Extrinsic factors govern human MAIT cell transcriptional and functional plasticity |
| Duncan R Mckenzie, United Kingdom – Normality-Sensing Licenses Local T cells for Innate-like Tissue-surveillance |
| Workshop – WS.T1.08 |
| Immune Response in Disease |
| Date & Time: September 3, 2021 / 09:30 – 10:45 |
| Chairs: TBA |
| Sergio Gil Manso, Spain – ABO-group and age are individuals factors associated with specific T-cell memory in long-term immunity after COVID-19 |
| Bérengère Salomé, United States – NKG2A and HLA-E define an additional immune checkpoint axis in bladder cancer |
| Anastasia Prokopi, Netherlands – High dimensional analysis of the human lymph node during melanoma progression reveals shifts in myeloid content that relate to differential T cell content |
| Rémi Marrocco, France – Themis1/vav1 signaling hub controls t cell pathogenicity in a mouse model of multiple sclerosis |
| Acelya Yilmazer Kirgin, Germany – Distinct Roles of Foxp3+ Regulatory T Cell Sublineages in Adipose Tissue Homeostasis and Obesity |
| Stefan Meltendorf, Germany – Insufficient up-regulation of YB-1 leads to failed CD4+ T cell survival of patients with SLE |
| Mustafa Kaya, Turkey – Role of Treg/Th17 Imbalance at the Immunity or Tolerance in Myasthenia Gravis |
| Workshop – WS.T1.09 |
| Myeloid Lineage |
| Date & Time: September 1, 2021 / 16:00 – 17:15 |
| Chairs: TBA |
| Tim Willinger, Sweden – Distinct developmental pathways from blood monocytes generate human lung macrophage diversity |
| Calum C Bain, United Kingdom – Dissecting the transcriptional control of airway macrophages: a key role for EGR2 |
| Xin Lei, Netherlands – Flagellin/TLR5 stimulate myeloid progenitors to enter lung tissue and to locally differentiate into macrophages |
| Sophiya Tabassum Tahir Siddiqui, Germany – Targeting lipid droplet metabolism in tumor associated macrophages as a novel approach to target tumor progression |
| Jake Thomas, United Kingdom – Identification and characterisation of Hofbauer cell progenitors in the first trimester human placenta |
| Jesper Van Eck Van Der Sluijs, Netherlands – High-dimensional flow-cytometry and functional evaluation reveals enhanced potency of stem cell-derived dendritic cell bulk vaccination to boost T cell immunity |
| Laura Marongiu, Italy – Molecular signature of conventional dendritic cell subtypes in COVID-19 disease |
| Workshop – WS.T1.10 |
| T Lymphocyte Regulation and Function |
| Date & Time: September 3, 2021 / 17:15 – 18:30 |
| Chairs: TBA |
| Mariana Borsa, United Kingdom – Retaining memory: Virtual memory CD8+ T cells as an adaptive mechanism of the ageing immune system |
| Svenja Rapelius, Germany – T cell stemness during chronic infection is maintained by only a subcompartment of TCF1+ cells |
| Katharina Hochheiser, Australia – ¬¬Protein tyrosine phosphatase non-receptor type 2 and killer cell lectin-like receptor G1 regulate the generation and function of tissue-resident memory T cells in skin |
| Cansu Yerinde, Germany – HDAC7 controls CD8+ T cell dependent anti-viral and anti-tumor immunity |
| Ling Li, Netherlands – Bryostatin exerts anti-tumor effects by reversing T cell exhaustion |
| Maria Davern, Ireland – Cooperation between chemotherapy and immunotherapy to enhance anti-tumour T-cell mediated immunity in oesophageal adenocarcinoma; implications for synergistic combination regimens |
| Christina Zielinski, Germany – Single-cell chimerism analysis and transcriptional profiling identify long-term human tissue-resident host T cells in the skin after allogeneic stem cell transplantation |
| Molecular and Cellular Mechanisms |
| Date & Time: September 4, 2021 / 12:00 – 13:15 |
| Chairs: TBA |
| Maria Metsger, Czech Republic – Identification of a CD106+ pericyte stem cell leading to Ly6G+ cell accumulation responsible for resistance to immunotherapy in pancreatic cancer |
| Zhichong Wu, France – Identification of a CD106+ pericyte stem cell leading to Ly6G+ cell accumulation responsible for resistance to immunotherapy in pancreatic cancer |
| Diletta Di Mitri, Italy – Heterotypic signaling between tumor cells and lipid-loaded macrophages drives tumor progression and resistance to therapy in cancer |
| Yingying Wei, China – JAK2/STAT5 signaling controls T cell polarization and development of experimental autoimmune encephalomyelitis |
| Thomas Riffelmacher, United States – Metabolic Fuel Choices Control MAIT Cell Functions at Homeostasis and after Infection |
| Thomas Liechti, United States -Leveraging high-dimensional flow cytometry to assess human immune homeostasis at population-wide scale |
| Simge Senay, Turkey – The effect of High-Density Lipoprotein (HDL) on autophagy and mitochondrial dynamics in a monocytic cell line |
Molecular Immunology Workshops
| Workshop – WS.T2.01 |
| Immune Regulation and Signaling |
| Date & Time: September 1, 2021 / 16:00 – 17:15 |
| Chairs: TBA |
| Felix Bayerl, Germany – PGE2 signaling reprograms the cDC1 transcription factor network to promote cDC1 dysfunctionality in tumors and limit cancer immune control |
| Ioannis Kienes, Germany – DDX3X Links NLRP11 to the Regulation of Type I Interferon Responses and NLRP3 Inflammasome Activation |
| Fiona Leslie, United Kingdom – Defining the rapid actions of glucocorticoids in the lung |
| Anna S Tocheva, United States – Functional T cell diversity drives differences in PD-1 signaling |
| Kata Petra Szilveszter, Hungary – Characterizing the Role of PLCγ2 in Autoantibody-induced Skin Blistering |
| Iva Hafner Bratkovic, Slovenia – Molecular mechanisms of NLRP3 inflammasome activation and its regulation |
| Pablo Pelegrín, Spain – Sensing low intracellular potassium by NLRP3 results in a stable open structure that promotes inflammasome activation |
| Workshop – WS.T2.02 |
| Immune Regulaltion and Transcriptional modulation |
| Date & Time: September 1, 2021 / 11:15 – 12:30 |
| Chairs: TBA |
| Sofia Piepoli, Turkey – Sibling rivalry among the ZBTB transcription factor family: homo vs heterodimerization |
| Lili Gu, Ireland – MNDA controls the pathogen-stimulated type I interferon cascade in human monocytes by transcriptional regulation of IRF7 |
| Sudheendra Hebbar Subramanyam, Germany – Foxp3-specific deletion of CREB generates Th2 biased ST-2 positive regulatory T-cells with enhanced IL-10 production and suppressive capacity |
| Panagiota Davoulou, Greece – The molecular interplay of Ets-2-Tip60 and its role in the pathogenesis of multiple sclerosis (MS) |
| Nivas Shyamala, India – HMGCR gene polymorphisms (rs33761740, rs3846662) and promoter DNA methylation association with serum lipids in coronary artery disease |
| Stefan Floess, Germany – Organ-specific inflammation-driven changes in the epigenetic signature of murine ILC2s |
| Shafaqat Ali, Germany -The transcription factor BATF limits the expression of type I interferon in plasmacytoid dendritic cells |
| Workshop – WS.T2.03 |
| Immune Response Regulation: Metabolism |
| Date & Time: September 2, 2021 / 11:30 – 12:45 |
| Chairs: TBA |
| Carlos Plaza Sirvent, Germany – The autophagy core protein ATG5 is essential to maintain intestinal RORgt+ Foxp3+ Treg cells |
| Lea Katharina Boller, Germany – Effect of glucose-transporter inhibitors on the function of Natural Killer cells |
| Belen Garcia Fojeda, Spain – Alveolar lipids regulate the response of alveolar macrophages to IL-4 |
| Remsha Afzal, Ireland – Mitochondrial arginase-2 is essential for IL-10 mediated metabolic reprogramming of inflammatory macrophages |
| Shannon L Cox, Ireland – Circadian disruption increases the inflammatory response of lung fibroblasts |
| Sue Mckay, Netherlands – Pectic polysaccharide RG-I from bell pepper and carrot stimulates protective innate immune responses and modulates gut microbiota in humans |
| Gabriela Sarango, France – The autophagy receptor TAX1BP1 (T6BP) is a novel player in viral antigen presentation by MHC-II molecules |
| Workshop – WS.T2.04 |
| Immune Response Regulation in Diseases |
| Date & Time: September 4, 2021 / 12:00 – 13:15 |
| Chairs: TBA |
| Eveline Le Nours, Sweden – Anti-MDA5 autoantibodies in myositis patients specifically target the Helicase domains of the MDA5 protein |
| Tamara Verkerk, Netherlands – Expression of neolacto-series glycosphingolipids by tumors impairs the function of low-affinity immune receptor-ligand pairs |
| Karina Pino Lagos, Chile – Small extracellular vesicles obtained from Nrp1+ T regulatory cells favor skin graft tolerance |
| Evelyn Kelemen, Hungary – PRINS long non-coding RNA regulates IL-23 expression of keratinocytes |
| Christina Molina Lopez, Spain – Activation mechanism and secretome characterization of NLRP3 mutants associated to cryopyrin periodic syndromes |
| Karen Yu, Belgium – Discovery of citrullination of MMP-9 in rheumatoid arthritis synovial fluid |
| Sara Abouelasrar, Belgium – The inflammatory nature of serum amyloid A (SAA): fact or fallacy? |
| Workshop – WS.T2.05 |
| Immune Regulation by Immune Receptors |
| Date & Time: September 4, 2021 / 12:00 – 13:15 |
| Chairs: TBA |
| Julian P Vivian, Australia – Structural plasticity of KIR2DL2 and KIR2DL3 enables altered docking geometries atop HLA-C |
| Jerome Le Nours, Australia – The structure of the marsupial γμ T cell receptor defines a third T cell lineage in vertebrates |
| Xiaoli Yang, Germany – The natural ompound Beauvericin exhibits immunostimulatory effect on dendritic cells via activating TLR4 signaling pathways |
| Helen Von Richthofent, Netherlands – Signal Inhibitory Receptor on Leukocytes-1 is an inhibitory Pattern Recognition Receptor that recognizes bacterial and endogenous amphipathic α-helical peptides |
| Marie Astrid Boutet, France – Pentraxin-3 (PTX3) Circulating And Synovial Expression Levels Correlate With Rheumatoid Arthritis Severity And Tissue Infiltration Independently Of The Response To Conventional Treatments |
| Rebeca F Megino, Spain – Cells deficient in membrane complement regulators as biosensors of abnormal complement deposition |
| Dayana Hristova, United Kingdom – DNA-PK is required for viral DNA sensing in human cells |
| Workshop – WS.T2.06 |
| Immune Regulation and Big Data |
| Date & Time: September 4, 2021 / 10:30 – 11:45 |
| Chairs: TBA |
| Gregory Ehx, Belgium – BamQuery: A new proteogenomic tool to explore the immunopeptidome and validate tumor-specific antigens |
| Necla Kochan, Turkey – Discovery of subtype specific markers through Fuzzy Logic and Non-parametric approaches using Transcriptomic data in immune related Colon cancer |
| Virginia Smit, Netherlands – Single-cell profiling of age-associated immunity in murine atherosclerosis |
| Ozlem Bulut, Netherlands – Identification of Common Metabolic Markers of Immune Aging In Western European and African Populations |
| Lorenzo Bonaguro, Germany – Natural human variation in multi-layered cohorts predicts the function of CRELD1: a novel regulator of immune homeostasis in mouse and human |
| Christos Nikolaou, Germany – Mass cytometry analysis of the murine hematopoietic system reveals signatures induced by ageing and physiological pathogen challenges |
| Timurs Maculins, United States – Multiplexed proteomics of autophagy deficient macrophages reveals enhanced antimicrobial immunity via the oxidative stress response |
Diseases and Immune Responses Workshops
| Workshop – WS.T3.01 |
| Allergy and asthma |
| Date & Time: September 1, 2021 / 11:15 – 12:30 |
| Chairs: TBA |
| Iris Bellinghausen, Germany – Oral administration of short chain fatty acids to PBMC-engrafted humanized mice prevents allergen-dependent airway and intestinal inflammation |
| Mathias Hochgerner, Austria – Hypoxia ameliorates allergic asthma {in vivo} by interfering with immune cell cross-talk |
| Pattraporn Satitsuksanoa, Switzerland – Characterisation of allergen-specific B cell tolerance in children with cow’s milk-oral immunotherapy and natural outgrow of milk allergy |
| Willem Van De Veen, Switzerland – In depth analysis of the bee venom allergen-specific B cell repertoire in immunotherapy-treated venom allergic individuals and naturally exposed healthy beekeepers |
| Mareike Ahrends, Germany – Asthma-associated immunological responses in RSV infections on primary human lung tissue {ex vivo} |
| Charlotte Castenmiller, Netherlands – The major peanut allergens Ara h 1, 2, 3 and 6 are taken up by dendritic cells via different routes and receptors |
| Xinran Zhao, Sweden – Mast cell chymase affects the functional properties of primary human lung fibroblast: implications for asthma |
| Workshop – WS.T3.02 |
| Cellular Mechanism of Inflammatio |
| Date & Time: September 1, 2021 / 13:00 – 14:15 |
| Chairs: TBA |
| Riem Gawish, Austria – Determinants of susceptibility in mice infected with mouse-adapted SARS-CoV-2 |
| Sarajo Mohanta, Germany – Neuroimmune Cardiovascular Interfaces in Atherosclerosis |
| Silvia Ariño, Spain – Infiltrating neutrophils present an aged phenotype and an altered recruitment dynamics and functionallity in chronic liver disease |
| Rafael Blanco Dominguez, Spain – CD69 expression on regulatory T cells protects from immune-mediated damage after myocardial infarction |
| Mehmet Ceylan, Turkey – Colchicine limited secondary lung injury in an experimental rat sepsis model |
| Milica Vujičić, Sweden – Critical role of resident M2-like macrophages in healthy subcutaneous adipose tissue expansion |
| Tanja Džopalić, Serbia – The role of interleukin-6 in pathogenesis of apical periodontitis studied by flow cytometry and cell cultures |
| Workshop – WS.T3.03 |
| Molecular Mechanisms of Inflammation |
| Date & Time: September 1, 2021 / 11:15 – 12:30 |
| Chairs: TBA |
| Prasenjit Mitra, India – Assessment of changes in the expression of immunomodulatory miRNAs (miR-20b, miR-155 and miR-221) in workers occupationally exposed to Cadmium |
| Nikolina Mihaylova, Bulgaria – Anti-inflammatory effect of Crocus sativus extract evaluated in a murine model of osteoarthritis |
| Yasmina Esther Hernández Santana, Ireland – Regulation of IL-36 receptor driven skin in inflammation in psoriasis |
| Lauren E. Fagan, Ireland – A Novel Role for Nutrient Receptors in Cartilage and Joint Disease |
| Radha Asher, United Kingdom – Glycolysis is a key driver of tissue degradation and remodelling in tuberculosis |
| Xinxin Luo, Sweden– Liver X receptor activation promotes intestinal repair while limiting tumorigenesis |
| Daniel Leonard Seiler, Germany – C5aR2 deficiency ameliorates inflammation in antibody transfer-experimental {epidermolysis bullosa acquisita} and reveals promoting of C5aR1 signaling outcomes |
| Workshop – WS.T3.04 |
| Exploiting host pathogen interaction |
| Date & Time: September 4, 2021 / 10:30 – 11:45 |
| Chairs: TBA |
| Raffaella Parente, Italy – The long pentraxin PTX3 at the host-pathogen interface in {Staphylococcus aureus}-dependent osteomyelitis |
| Matthieu Paiola, United States – Role of MHC class I-like XNC4 during mycobacterial infection in two developmental stages in {Xenopus} |
| Alanna M Kelly, Ireland – {Staphylococcus aureus}-induced immunosuppression facilitates persistence during nasal colonisation |
| Tobias K Dallenga, Germany – Prevention of Mycobacterium tuberculosis-induced neutrophil necrosis restricts bacterial proliferation and may represent a target for a host-directed therapy |
| Gul Kilinc, Netherlands – Development and employment of a human cell-based {in vitro} {Mycobacterium avium} infection model to identify host-directed therapeutics as a novel treatment strategy |
| Julia Kutschenreuter, United Kingdom – Neutrophil-dependent secretion of the biomarker LRG1 in Tuberculosis |
| Sebastian Baasch, Germany – Cytomegalovirus subverts macrophage identity |
| Workshop – WS.T3.05 |
| Genetic and environmental triggers of autoimmunity |
| Date & Time: September 1, 2021 / 13:00 – 14:15 |
| Chairs: TBA |
| Cristoforo Grasso, Netherlands – Identification and mapping of distinct human lymph node stromal cell subsets by combining single cell RNA sequencing with spatial transcriptomics |
| Alice Lepelley, France – cGAS-STING-dependent interferon signalling in a mitochondrial disease |
| Jamie van Langelaar, Netherlands – Preferential induction of brain-homing T-bet+ B cells by infectious triggers in multiple sclerosis patients |
| Bert Malengier Devlies, Belgium – Lung Functioning and Inflammation in a Mouse Model of Systemic Juvenile Idiopathic Arthritis |
| Etienne Masle Farquhar, Australia – EGR2 and EGR3 prevent uncontrolled accumulation of B1 and CD21low age-associated B cells |
| Maartje G Huijbers, Netherlands – Functional monovalency of IgG4 autoantibodies amplifies their pathogenicity in MuSK myasthenia gravis |
| María Botía Sánchez, Spain – Characterising the relation between genetic background and gut immune response against microbiota in a murine model of lupus |
| Workshop – WS.T3.06 |
| Immune deficiencies |
| Date & Time: September 1, 2021 / 16:00 – 17:15 |
| Chairs: TBA |
| Sevil Oskay Halaçlı, Turkey – The imbalance of the circulating regulatory B cell subsets in patients with primary immunodeficiencies |
| Manfred Anim, Germany – Novel heterozygous missense mutations in NFkB1 causes immunedysregulation and immunodeficiency |
| Marion Ciudad, France – Warm autoimmune hemolytic anemia is associated with a regulatory T cell deficiency and a Th17 polarization |
| Liat Stoler Barak, Israel – The role of DYRK1A in B cell immune responses |
| Meryem Demir, Turkey – COVID-19 in patients with primary and secondary immunodeficiencies: A single-center experience |
| Jiahui Luo, China – Targeted inhibition of FTO demethylase protects mice against LPS-induced septic shock by suppressing NLRP3 inflammasome |
| Merve Selcuk, Turkey – CHAPLE Disease and Non-CHAPLE Protein Losing Enteropathies: Natural History and Immune Characteristics |
| Workshop – WS.T3.07 |
| Immune regulation in cancer |
| Date & Time: September 3, 2021 / 09:30 – 10:45 |
| Chairs: TBA |
| Paulo Rodrigues Santos, Portugal -Immune profiling of soft tissue sarcoma: cellular, proteomic and transcriptomic analysis of peripheral blood |
| Alexander Simpson, United Kingdom – FcγRIIB-mediated inhibition of antibody-mediated target cell depletion is independent of ITIM signalling |
| Marina Patysheva, Russia – СD14low16highHLA-DR+ monocytes are increased in breast cancer patients with good response to neoadjuvant chemotherapy |
| Suzanne M Castenmiller, Netherlands – Cytokine-producing tumor-infiltrating lymphocyte products can be effectively generated from pre-treated late stage non-small-cell lung cancer (NSCLC) lesions irrespective of location and pre-treatment regimens |
| Monika Homolya, Austria – Downregulation of A20 promotes immune escape of lung adenocarcinomas |
| Yvonne Vercoulen, Netherlands – Single cell spatial analysis reveals changes in the tissue immune landscape during initiation of colitis associated cancer in patients |
| Domenico Supino, Italy – IL-1R8 acts as an immune checkpoint in CD8+ T cells |
| Workshop – WS.T3.08 |
| Maintenance and local regulation of tissue specific immunity |
| Date & Time: September 2, 2021 / 11:30 – 12:45 |
| Chairs: TBA |
| Michael Dudek, Germany – Auto-aggressive CXCR6+ CD8 T cells cause liver immune pathology in NASH |
| Lilja Hardardottir, Germany – The critical expansion of uterine CD8+ T cells in pregnancy is under tight homeostatic control |
| Alexandra Argyriou, Sweden – Single cell sequencing reveals expanded cytotoxic CD4+ T cells and two states of peripheral helper T cells in synovial fluid of ACPA+ Rheumatoid Arthritis patients |
| Christian Schwartz, Germany – Innate PD-L1 limits T cell mediated adipose tissue inflammation |
| Hendrika W Grievink, Netherlands – Stimulation of the PD-1 pathway decreases atherosclerotic lesion development in Ldlr deficient mice |
| Masa Filipovic, Croatia – Increased inflammatory parameters, chemokines and chemokine receptors in obese children |
| Gráinne Jameson, Ireland – Human intrahepatic CD56bright NK cells display a tissue-resident transcriptional profile and enhanced ability to kill allogenic CD8+ T cells |
| Workshop – WS.T3.09 |
| Microbial, fungal, and parasitic immunology |
| Date & Time: September 2, 2021 / 17:15 – 18:30 |
| Chairs: TBA |
| Giulia Stucchi, Italy – Role of danger and microbial signals in the control of the recruitment of neutrophil subpopulations during infections |
| Matthias H Enders, Australia – Liver resident CD4 T cells in malaria infection |
| Mimmi L E Lundahl, Ireland – Macrophage Innate Training Induced by IL-4 Activation Enhances OXPHOS Driven Anti-Mycobacterial Responses |
| Thierry Roger, Switzerland – Trained immunity confers prolonged protection against systemic listeriosis |
| Marco De Zuani, Czech Republic – Sepsis induces long-term reprogramming of human hematopoietic stem cells |
| Mads Delbo Larsen, Netherlands – Afucosylated IgG is naturally produced in response to intracellular pathogens including SARS-CoV-2 and {Plasmodium falciparum} but not by subunit vaccination |
| Antonio Inforzato, Italy – The alternative pathway of complement and long pentraxin PTX3 form a functional axis in the immune response to Aspergillus fumigatus |
| Workshop – WS.T3.10 |
| T Cells in Atopy, Transplantation and Tolerance |
| Date & Time: September 4, 2021 / 12:00 – 13:15 |
| Chairs: TBA |
| Joyce Lübbers, Netherlands – Tolerance induction with vitamin D3, Dexamethasone or sialic acids influences maturation status and metabolic activity in human dendritic cells |
| Thiruni N Adikari, Australia – Single cell RNA sequencing of gluten-specific CD4+ T cells reveals a novel gene expression pattern with NK-like cytotoxicity |
| Olatz Zenarruzabeitia, Spain – PD-1 expressing regulatory T cells and basophils with an activating profile in infants with moderate-to-severe Atopic Dermatitis hypersensitized to food antigens |
| Marygrace Duggar, United States – The role of DRAK2 in Graft versus Host Disease |
| Anton Althammer, Germany – CD28 Superagonist TAB08-mediated activation and expansion of human regulatory T cells might protect patients from acute Graft versus Host Disease |
| Maria Luisa Del Rio Gonzalez, Spain – CD160, a CD28 alternative costimulatory molecule of alloreactive CD8 T cells unable to prevent NK cell-mediated mechanisms of rejection |
| Johanna Strobl, Austria – Re-circulating tissue-resident memory T cells are poised for a systemic Th2-driven host-versus-graft reaction after human allogeneic hematopoietic stem cell transplantation |
| Workshop – WS.T3.11 |
| Microbiota and Mucosa |
| Date & Time: September 4, 2021 / 12:00 – 13:15 |
| Chairs: TBA |
| Israel Olivas Martinez, Spain – Dysbiosis in gut mucosa in relation to CD4 counts at cART onset and CD4 recovery |
| Lisa Budzinski, Germany – Using multiparameter flow cytometry to understand microbiota-host crosstalk in chronic inflammatory diseases |
| Ana Santos Almeida, Ireland – Fibre-associated Lachnospiraceae reduce colon tumorigenesis by modulation of the tumour-immune microenvironment |
| Marketa Vavreckova, Czech Republic – High-protein diet and TLR9 knock out effect on the immune responses in the development of colorectal cancer |
| Jenny Mary Mannion, Ireland – Potential pathogenic role for respiratory symbionts in the development of self-reactive Th17 cells |
| Diana Elena Matei, United Kingdom – Intestinal barrier dysfunction plays an integral role in arthritis pathology and can be targeted to ameliorate disease |
| Marc Lindenberg, Germany – Clarithromycin impairs tissue-resident memory and Th17 responses to macrolide-resistant {Streptococcus pneumoniae} infections |
| Workshop – WS.T3.12 |
| Mucosal Immunity |
| Date & Time: September 3, 2021 / 17:15 – 18:30 |
| Chairs: TBA |
| Federica Laudisi, Italy -GATA6 deficiency leads to epithelial barrier dysfunction and enhances susceptibility to gut inflammation |
| Marilena Letizia, Germany – Store-operated calcium entry controls immune cell function and activation in inflammatory bowel disease |
| Daniëlle M.H. Barendregt, Netherlands – Expression of the coinhibitory receptor TIGIT on memory CD4+ T cells is induced by TCR ligation and retinoic acid co-stimulation and is elicited during microbial colonization of the intestine |
| Mangge Zou, Germany – Early-life vitamin A treatment rescues neonatal infection-induced long-lastingly impaired lymph node operativeness |
| Jochen Mattner, Germany – Arginase 1 inhibits the resolution of colitis due to the consumption of L-arginine and the expansion of an inflammatory microbiota |
| Laura F. Ouboter, Netherlands – Identification of a disease-associated network of intestinal immune cells in treatment-naïve inflammatory bowel disease |
| Jonathan Wai Pang Lo, United Kingdom – Immune checkpoint inhibitor-induced colitis is mediated by IL23 responsive CD90+ cytotoxic lymphocytes |
| Workshop – WS.T3.13 |
| Neuroinflammation |
| Date & Time: September 2, 2021 / 17:15 – 18:30 |
| Chairs: TBA |
| Emeline Joulia, France – Eomes controls central nervous system inflammation by increasing survival of effector CD4 T cells through the regulation of mitochondrial metabolism |
| Steven Koetzier, Netherlands – Towards the suppression of the disease-relevant brain-homing CD4+ T cell in multiple sclerosis |
| Zhana Haimon, Israel – Defining the role of microglia in Relapsing-Remitting EAE |
| Doryssa Hermans, Belgium – Oncostatin M opens the gate for T helper 17 cells during neuroinflammation |
| Henning Ulrich, Brazil – Kinin-B2 receptor signaling in neuroinflammation and innate immune response in Alzheimer’s disease |
| Malgorzata Krzyzowska, Sweden – Fas/FasL contributes to HSV-1 brain infection and neuroinflammation |
| Judith Fraussen, Belgium – Circulating immune profile changes reflect memory immune responses in spinal cord injury patients |
| Workshop – WS.T3.14 |
| Tumor microenvironment |
| Date & Time: September 3, 2021 / 17:15 – 18:30 |
| Chairs: TBA |
| Silvia Carnevale,Italy – Neutrophils controlling the intestinal microbiota provide protection against colitis and colitis-associated colorectal cancer |
| Hannah Egan, Ireland – The T-cells Sweet Tooth: T-lymphocytes exposed to highly sialylated cancer associated fibroblasts present an exhausted phenotype, which can be reversed through desialylation |
| Luigi D’Antonio, Italy – Hindering triple negative breast cancer progression by targeting endogenous Interleukin-30 requires IFNγ signaling |
| Yasmine Lounici, France – Complementary but distinct protective roles of breast tumor-infiltrating IgG and IgA producing cells |
| Marie Laviron, France – Tumor-associated macrophages heterogeneity is driven by distinct niches in breast cancer |
| Costanza Maria Cristiani, Italy – Frequencies and functional properties of Innate Lymphoid Cells are altered in melanoma patients and modulated by immune checkpoints inhibitors |
| Ioana Plesca, Germany – Tumor-infiltrating plasmacytoid dendritic cells are associated with survival in human colon cancer |
| Workshop – WS.T3.15 |
| Immunoregulation and Tumor microenvironment |
| Date & Time: September 4, 2021 / 10:30 – 11:45 |
| Chairs: TBA |
| Mussarat Wahid, United Kingdom – Targeting PD1/PDL1 pathway by endogenous recombinant soluble PD1 |
| Samuele Notarbartolo, Italy – Single-cell transcriptional and repertoire profiling of CD4+ TILs unveils distinct immune evasion strategies in primary and metastatic CRC |
| Felix Simon Ruben Picard, Germany – IL-17-producing CD8 T cells associate with poor survival in PDAC and promote carcinogenesis via induction of inflammatory cancer associated fibroblasts |
| Julian Swatler, Poland – Leukemic extracellular vesicles drive highly suppressive regulatory T cells by modulating mTOR and STAT5 signaling, leading to progression of myeloid leukemia |
| Pia Gamradt, France – Alk4 disruption in Kras-induced pancreatic cancer remodels mechanical and immunologic properties of the tumor microenvironment |
| Alexander Visekruna, Germany– Depending on the tumor microenvironment, immunoproteasomes exert pro- or anti-tumorigenic effects |
| Tatjana Bilich, Germany – Characterization of pre-existing and post-infectious immune responses to SARS-CoV-2 in cancer patients |
| Workshop – WS.T3.16 |
| Viral Immunology 1 |
| Date & Time: September 3, 2021 / 14:30 – 15:45 |
| Chairs: TBA |
| Valeria Fumagalli, Italy – Group 1 innate lymphoid cells regulate T cell-mediated liver immunopathology by controlling local interleukin-2 availability |
| Ezgi Akidil, Germany – Highly efficient CRISPR-Cas9-mediated gene knockout in primary human B cells for functional genetic studies of Epstein-Barr virus infection |
| Claudia De Pasquale, Italy – Hepatitis B virus negatively impacts the protective Immune crosstalk between Natural Killer and Dendritic Cells |
| Simona Saluzzo, Austria – Loss of skin CXCR3+ CD4+ tissue-resident T cells causes irreversible skin-confined immunodeficiency in HIV late presenters |
| Laura Ospina Quintero, Germany – A two-photon imaging platform for investigating cytotoxic T lymphocyte dynamics in virus-infected explanted lungs |
| Lavinia Franchitti, United States – CD8+ lymphocyte mediated suppression of HIV expression in CD4+ T cells |
| Tomer Hertz, Israel – IgA immune history profiles predict influenza disease in vaccinated and unvaccinated individuals |
| Workshop – WS.T3.17 |
| Viral Immunology 2 |
| Date & Time: September 3, 2021 / 09:30 – 10:45 |
| Chairs: TBA |
| Hannah Kaminski, France – mTOR inhibitors prevent CMV infection through the restoration of functional gamma-delta and alpha-beta T cells in kidney transplantation |
| Martina Anzaghe, Germany – Type I interferon receptor-independent interferon-alpha induction upon infection with a variety of negative-strand RNA viruses |
| Francesco Andreata, Italy – Identification of a Kupffer cell subset capable of reverting the T cell dysfunction induced by hepatocellular priming |
| Eleonora Sala, Italy – Dissecting the role of IFN-𝛾 in antiviral CD4+ T cell fate |
| Marwa Abd Alhadi, Israel – Obesity is associated with an altered baseline and post-vaccination influenza antibody repertoire |
| Jonathan M Gibbins, United Kingdom – Aberrant glycosylation of anti-SARS-CoV-2 IgG is a pro-thrombotic stimulus for platelets |
| Jun Siong Low, Switzerland – A rapid screening strategy identifies a pan-coronavirus neutralizing antibody |
| Workshop – WS.T3.18 |
| COVID 19 – 1 |
| Date & Time: September 3, 2021 / 14:30 – 15:45 |
| Chairs: TBA |
| Seppe Cambier, Belgium – Kinetics of peripheral blood neutrophils in severe coronavirus disease 2019 |
| Sara Falck Jones, Sweden – Functional monocytic myeloid-derived suppressor cells increase in blood but not airways and predict COVID-19 severity |
| Anna C. Aschenbrenner, Germany – Disease severity-specific neutrophil signatures in blood transcriptomes stratify COVID-19 patients |
| Julia Eder, Netherlands – Infection and transmission of SARS-CoV-2 depends on heparan sulfate proteoglycans |
| Julia Niessl, Sweden – Identification of SARS-CoV-2-cross-reactive resident memory CD8+ T cells in oropharyngeal lymphoid tissue |
| Digdem Yoyen Ermis, Turkey – The distribution of mature and/or immature myeloid cells and their role in effective anti-viral immune responses in COVID-19 positive patients |
| Alberto Utrero Rico, Spain – Changes in circulating monocytes predict severity during acute COVID-19 and include chromatin modifications still detectable six months after recovery |
| Workshop – WS.T3.19 |
| COVID 19 – 2 |
| Date & Time: September 4, 2021 / 10:30 – 11:45 |
| Chairs: TBA |
| Cevriye Pamukcu, Turkey – A Colorimetric Pseudovirus-based Assay Using Secreted Embryonic Alkaline Phosphatase for Analysis of Neutralizing Activity Against SARS-CoV-2 |
| Fatma Savran Oguz, Turkey – The influence of HLA genotype on the severity of COVID-19 infection |
| Büşranur Geçkin, Netherlands – The BNT162b2 mRNA vaccine against SARS-CoV-2 reprograms both adaptive and innate immune responses |
| Ljiljana Sofronic Milosavljevic, Serbia – Immunomodulatory Effect of IgM/IgA-enriched High Dose Intravenous Immunoglobulin Therapy in Covid-19 Patients |
| Jonas Schulte-Schrepping, Germany – Severe COVID-19 Is Marked by a Dysregulated Myeloid Cell Compartment |
| Chiara E. Geyer, Netherlands – Hyper-inflammation in severely ill COVID-19 is induced by early phase anti-SARS-CoV-2 IgG and can be specifically counteracted by FDA/EMA-approved small molecule inhibitors |
| Abdurrahman Simsek, Turkey – Peripheral CD39-expressing regulatory T cell subsets play an age-dependent role in the severity of COVID-19 |
| Workshop – WS.T3.20 |
| COVID 19-3 |
| Date & Time: September 4, 2021 / 12:00 – 13:15 |
| Chairs: TBA |
| Patricia Suàrez Fernández, Spain – Circulatory T Follicular Helper cell (cTFH) profile during SARS-CoV-2 infection |
| Jyothi N. Purushotham, United States – Multi-omics analysis of the age-related effects of SARS-CoV-2 infection in rhesus macaques |
| Jet Van Den Dijssel, Netherlands – Parallel detection of SARS-CoV-2 epitopes in convalescent COVID-19 patients reveals immunodominance and memory CD8+ T cells |
| Caoimhe H. Kiernan, Netherlands – SARS-CoV-2-specific T cell immunity is retained 12 months post-infection and is dependent on CD4 T cells |
| Kilian Schober, Germany – Single-cell RNA sequencing reveals in vivo signatures of SARS-CoV-2-reactive T cells through ‘reverse phenotyping’ |
| Lisan Kuijper, Netherlands – Deep immune phenotyping of SARS-CoV-2 specific B cell profiles after primary infection |
| Alessio Mazzoni, Italy – First-dose mRNA vaccination is sufficient to reactivate immunological memory to SARS-CoV-2 in recovered COVID-19 subjects |
| Workshop – WS.T3.21 |
| Inflammation and genetic effects |
| Date & Time: September 4, 2021 / 12:00 – 13:15 |
| Chairs: TBA |
| Sanne Mol, Netherlands – Hyaluronic acid in synovial fluid in inflamed joints inhibits neutrophil activation |
| Matheus Silvério Mattos, Belgium – Prolonged neutrophil survival at necrotic sites is a fundamental feature for tissue recovery and resolution of hepatic inflammation |
| Catriona Walls, United Kingdom – The Role of Siglec-9 in ANCA-associated Vasculitis |
| Safa Baris, Turkey – Reversal clinical and immunological effects of abatacept in patients with LRBA and CTLA4 deficiencies |
| Tania Gajardo, France – TTC7A/PI4KIIIα pathway controls leukocytes’ migration |
| Elissa Deenick, Australia – Dissecting the cellular defects that lead to activated PI3K δ Syndrome (APDS) |
| Lukács Sándor Lesinszki, Hungary – Src-family kinases in immune complex-mediated glomerulonephritis |
| Diseases and Innovative Technologies |
| Date & Time: September 4, 2021 / 10:30 – 11:45 |
| Chairs: TBA |
| Elena Jachetti, Italy – Systems analysis reveals the unique immune system organization in the long-lived rodent Spalax |
| Rizwan Ahmed, United States – A novel monoclonal antibody (x-mAb) produced by a newly discovered lymphocyte (DE cells) identifies universal autoreactive T cells that are associated with self-related immunity |
| Ann Kathrin Reuschl, United Kingdom – Evolution of enhanced innate immune evasion in lung epithelial cells by the SARS-CoV-2 B.1.1.7 variant |
| Jasmin Scheurer, Germany -3D human skin models of inflammatory skin diseases psoriasis and atopic dermatitis |
| Piotr Trzonkowski, Poland -From bench to bedside – Clinical therapy with T regulatory cells |
| Sabriye Senem Kılıç, Turkey -Cellular Response of HaCaT Keratinocytes in Co-Culture With {Staphylococcus Aureus} in Bacterial Cellulose-Based Antibacterial Wound Dressings |
| Soren Reinke, United Kingdom – Novel adjuvants that promote the efficacy of R21 malaria vaccine candidate in a mouse model |
Innovative Technologies and Immunotherapies Workshops
| Workshop – WS.T4.01 |
| Bioinformatics and Immunology |
| Date & Time: September 1, 2021 / 11:15 – 12:30 |
| Chairs: TBA |
| Alexander Y Komkov, Russia – The hidden stage of V(D)J-recombination: examination of the first time discovered human TRB D1-D2 rearrangements repertoires |
| Charlotte L. Scott, Belgium – Using Spatial Proteogenomics to create a practical cell atlas of the murine and human liver |
| Daniel Toro Domínguez, Spain – Personalized molecular portraits of Systemic Lupus Erythematosus patients as key for prognosis and therapeutic decisions |
| Hadas Neuman, Israel – IgTreeZ: A toolkit for immunoglobulin gene lineage tree analysis |
| Stephanie C. Talker, Switzerland – Single-cell RNA sequencing reveals striking heterogeneity of mononuclear phagocytes in bovine mesenteric lymph nodes |
| Wojciech Lason, United Kingdom – Pan-cancer survey of tumour mass dormancy and underlying mutational processes |
| Matti Hoch, Germany – Investigating the role of multicomponent multitarget drug Tr14 in inflammation resolution using in silico perturbation experiments |
| Workshop – WS.T4.02 |
| Cancer Immunotherapy – Adaptive Immune Responses |
| Date & Time: September 3, 2021 / 17:15 – 18:30 |
| Chairs: TBA |
| Emre Balta, Germany – Antioxidant empowerment enhances antitumor functions of HER2-specific CAR T cells |
| Maik Luu, Germany – Microbial short-chain fatty acids enhance CD8+ T cell-mediated cancer immunotherapy |
| Maarten K. Nijen Twilhaar, Netherlands – Toll-like receptor ligand inclusion in GM3-containing liposomes induces potent dendritic cell maturation and T cell responses |
| Emiliya Stoyanova, Bulgaria – Anti-tumor Properties of Epitope-Specific Vaccine in Murine Model of Melanoma |
| Rebeca F Megino, Spain – Patient-specific cellular models for Sézary syndrome immunotherapy |
| Agata Mlynska, Lithuania – Modeling of dendritic cell vaccines for ovarian cancer immunotherapy using cell lines of different molecular profiles |
| Katharina Grabmeier Pfistershammer, Austria – Low frequency of differentiated CD3+CD27-CD28- T cells at enrollment predicts a favorable response to CAR T cell therapy in patients with DLBCL |
| Workshop – WS.T4.03 |
| Cancer Immunotherapy – Innate Immune Responses |
| Date & Time: September 4, 2021 / 12:00 – 13:15 |
| Chairs: TBA |
| Maria A Streltsova, Russia – Transduction of NK cells with TYPOBP gene increases their functional activity and the NKp44 receptor expression level |
| Eduardo Moreo, Spain – Intravesical bacterial immunotherapy for bladder cancer can elicit tumor-specific immunity and relies on the capacity of the bacteria to infect and persist in the bladder |
| Maite Alvarez, Spain– Intratumoral Co-injection of the Poly I:C-derivative BO-112 and a STING Agonist Synergize to Achieve Local and Distant Anti-tumor Efficacy |
| Yunjie Wu, Norway – NK cells release subsets of extracellular vesicles with distinct profiles and tumor-targeting abilities |
| Sen Ma, Netherlands – In vitro results of first in class targeted therapy in Uveal Melanoma suggest immunostimulatory capacity |
| Sandra Lara, Sweden – Intravesical bacterial immunotherapy for bladder cancer can elicit tumor-specific immunity and relies on the capacity of the bacteria to infect and persist in the bladder |
| Ekaterina Pylaeva, Germany – Targeting glycosaminoglycan-CCL2 interactions prevents the immunosuppressive polarization of myeloid cells and provides an anti-tumor immune response |
| Workshop – WS.T4.04 |
| Therapy in Autoimmunity and Allergies |
| Date & Time: September 2, 2021 / 17:15 – 18:30 |
| Chairs: TBA |
| Mercedes Lopez Santalla, Spain – Protective long-term effects of mesenchymal stromal/stem cell-based therapy in experimental colitis is mediated by induction of an innate immune memory-like response |
| Isabelle Ote, Belgium – MOG-derived Imotope™, inducing cytolytic CD4+ T cells and reducing EAE manifestations in mice, as novel antigen-specific immunotherapy for multiple sclerosis |
| Andres Paris, Spain – Functionalization of tolerogenic dendritic cells with iron oxide magnetic nanoparticles for their magnetic retention |
| Evelien Schurgers, Belgium – Immunotherapy with apitopes® blocks the immune response to S-antigen in HLA-DR transgenic mice |
| Hannah K Fitzgerald, Ireland -Aromatic ketoacids represent novel therapies for inflammatory diseases through activation of the Nrf2/HO-1 pathway and suppression of pro-inflammatory responses in primary human immune cells |
| Josefine Ruder, Switzerland – Immune Reconstitution after Autologous Hematopoietic Stem Cell Transplantation in Multiple Sclerosis |
| Nikola Ralchev Ralchev, Bulgaria – Selective elimination of allergen-specific B lymphocytes in chronic mouse house dust mite allergy model |
| Workshop – WS.T4.05 |
| Vaccines in Immunotherapy |
| Date & Time: September 1, 2021 / 11:15 – 12:30 |
| Chairs: TBA |
| Marina Bekić, Serbia – Phosphonated cellulose nanocrystals potentiate Th1 polarizing capacity of monocyte-derived dendritic cells |
| Noémi Anna Nagy, Netherlands – Liposomal vitamin D3 and retinoic acid induce tolerogenic dendritic cells |
| Marko Šustić, Croatia – Cytomegalovirus vector expressing NKG2D ligand generates superior CD8 T cell response with distinct phenotypical and functional features |
| Ioanna Zerva, Greece – Immunotherapy-on-chip against an experimental sepsis model |
| Lachlan Paul Deimel, United Kingdom – Mucosal administration of polyethylenimine in formulation with SARS-SoV-2 spike elicits potent neutralising responses |
| Jorieke Weiden, Switzerland – Probing the importance of valency and spatial organization of immune regulator PD-1 with DNA-based nanomaterials |
| Beka Solomon, Israel – Inhibition of endocytic BACE1 activity based on blocking the beta –secretase cleavage site on the APP via antibodies |
| Workshop – WS.T4.06 |
| Innovative Technologies and Immunotherapies |
| Date & Time: September 2, 2021 / 11:30 – 12:45 |
| Chairs: TBA |
| Antonia Efstathiou, Greece – Proteomic analysis of exosomes highlights their role in specific-signaling pathways’ modulation during Leishmania infection in macrophage |
| Charline Sommer, Germany – Drafting an evidence-based immune-related adverse outcome pathway of interleukin-2-induced adverse effects on human lung tissue |
| Thomas S Fulford, Australia – A lateral flow assay to detect neutralising antibodies against SARS-CoV-2 |
| Jorge Gallego-Valle, Spain – Avidin-based Universal CAR regulatory T cells (UniCAR-Tregs): a versatile approach for future immunotherapy |
| Alexander Leithner, United Kingdom – A supported lipid bilayer platform to study the impact of bi-specific engager architecture on T cell activation |
| Laura Wilkins, United Kingdom – Pembrolizumab drug levels and anti-drug antibodies: measurement in two real-world centres |
| Nuno GB Neto, Ireland – Single-cell metabolic profiling of macrophage polarization by fluorescence lifetime imaging microscopy (FLIM) |